While MURC is primarily structured to focus on statewide issues, many of the urban concerns MURC addresses are consistent with national public issues. Consequently, the activities of the Center include state regional and national projects.

African American Prevention Intervention Network (APIN )
The African American Prevention Intervention Network (APIN) is a project designed to assist African-American-serving community-based (CBOs) organizations, health departments and health department-funded CBOs with adaptation, implementation, quality assurance and evaluation of effective HIV prevention interventions through the Southern Prevention Intervention Center (S-PIC) and the Youths, Adolescents and Young Adults (YAYA) Center. Specifically, S-PIC focuses on high-risk seronegative and HIV-positive racial/ethnic minority individuals in the southern region of the United States, while YAYA focuses on youths in non-school settings including lesbian, gay, bi-sexual, transgender and questioning youths throughout the United States and its territories. The APIN builds capacity among CBOs and health departments through a variety of delivery mechanisms including: information transfer, skills-building, technical services, technical consultation and technology transfer.

Metro Jackson Community Prevention Coalition
MJCPC was formed in 1995 under the Center for Substance Abuse Prevention (CSAP) Community Prevention initiative. The Coalition is an expansion of an earlier CSAP five-year Community Partnership initiative "Jackson Takes A Stand Community Partnership". Currently, MJCPC is funded by the Mississippi Department of Mental Health.

Project Safe Neighborhoods
Project Safe Neighborhoods is a nationwide commitment to reduce gun crime in America by networking existing local programs that target gun crime and by providing those programs with additional tools necessary to be successful. Project Safe Neighborhoods will be implemented in a manner that is contoured to fit the specific gun crime problems in each of the nation’s 94 federal judicial districts. The Mississippi Urban Research Center will utilize its core services and current capacity to provide information to the task force for planning purposes and to offer support for task force activities and objectives.

U. S. Census Information Center (CIC)
Housed at MURC, the U. S. Census Information Center (CIC) is the only one of its kind in the State of Mississippi. CIC provides Census 2000 data to non-profit organizations in user-friendly formats. As a CIC walk-in site, MURC assists underserved populations by providing relevant data, statistics and reports for use in a variety of ways from program planning to market research.